Melon thrips, Thrips palmi (Karny, Thysanoptera: Thripidae) is a predominant thrips species in Asia. It has spread to Africa, Australia, America and is declared as a quarantine pest in Europe. It causes significant losses in cucurbits and solanaceous crops by rasping and sucking plant sap. Besides, it transmits several tospoviruses. T. palmi transmits more than seven tospoviruses. Among them. groundnut bud necrosis virus (GBNV) is the most economically important tospovirus in India, infects a variety of vegetable and ornamental plants. GBNV alone is responsible for more than US$89 million annual losses in Asia. T. palmi transmits the tospoviruses in a persistent propagative manner. Upon ingestion, tospovirus first infects the anterior midgut tissues of T. palmi. The infection disseminates to the primary salivary gland via a pair of connecting ligaments. Multiplication of tospovirus takes place mostly in midgut and primary salivary glands. Adults can only transmit the virus if virus acquisition takes place during early instar larva. Management of thrips vectors is the primary strategy for controlling tospoviruses. Wide application of insecticides for management of thrips causes several detrimental effects on the environment and beneficial insects. Interrupting the interrelationship between T. palmi and tospoviruses is a novel approach for management of this virus-vector complex. Little is known about the genes of T. palmi involved in GBNV transmission. Understanding the molecular interaction between GBNV and T. palmi, and interrupting the interrelationship may be a viable solution to manage the virus-vector complex. This study provides an understanding of T. palmi genes responsive to GBNV infection.